p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP

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p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP.

p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a central role in tumor suppression. In this study we investigated p21 protein expression and mutation in gastric adenocarcinoma. A total of 76 primary gastric carcinoma specimens were immunohistochemically stained for p21 protein ex...

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ژورنال

عنوان ژورنال: Journal of Korean Medical Science

سال: 1998

ISSN: 1011-8934,1598-6357

DOI: 10.3346/jkms.1998.13.5.507